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LC-MS/MS of different developmental stages of human pancreas

ABSTRACT: Mass spectrometry-based quantitative proteomics was used to delineate proteome-wide and extracellular matrix (ECM) alterations at four age groups in human pancreas: fetal (18-20 weeks gestation), juvenile (5-16 years old), young adults (21-29 years old) and older adults (50-61 years old).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreas

SUBMITTER: Zihui Li

LAB HEAD: Lingjun Li

PROVIDER: PXD020130 | Pride | 2021-01-06

REPOSITORIES: Pride

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			Action	DRS
	Pancrea_12plex_B1_Frac1_tr1.raw	Raw
	Pancrea_12plex_B1_Frac1_tr2.raw	Raw
	Pancrea_12plex_B1_Frac2_tr1.raw	Raw
	Pancrea_12plex_B1_Frac2_tr2.raw	Raw
	Pancrea_12plex_B1_Frac3_tr1.raw	Raw

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Publications

Proteome-wide and matrisome-specific alterations during human pancreas development and maturation.

Li Zihui Z Tremmel Daniel M DM Ma Fengfei F Yu Qinying Q Ma Min M Delafield Daniel G DG Shi Yatao Y Wang Bin B Mitchell Samantha A SA Feeney Austin K AK Jain Vansh S VS Sackett Sara Dutton SD Odorico Jon S JS Li Lingjun L

Nature communications 20210215 1

The extracellular matrix (ECM) is unique to each tissue and capable of guiding cell differentiation, migration, morphology, and function. The ECM proteome of different developmental stages has not been systematically studied in the human pancreas. In this study, we apply mass spectrometry-based quantitative proteomics strategies using N,N-dimethyl leucine isobaric tags to delineate proteome-wide and ECM-specific alterations in four age groups: fetal (18-20 weeks gestation), juvenile (5-16 years ...[more]

PMID: 33589611

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