Proteomics

Dataset Information

0

Naturally processed flucloxacillin haptenated HLA ligands

ABSTRACT: This study has demonstrated that natural flucloxacillin haptenated HLA-B*57:01 ligands arepresented by antigen presenting cells through multiple pathways. Identification of such epitopes will help to define the chemical signals responsible for drug-induced immunological disease.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Cell Suspension Culture

DISEASE(S): Hypersensitivity Reaction Type Iv Disease,Drug Allergy

SUBMITTER: James Waddington  

LAB HEAD: Xiaoli Meng

PROVIDER: PXD020137 | Pride | 2020-08-05

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
171024-JCWPepEluC1RB5701FluIP170928P118uLinject-Monashmethod-Monashgradient.mgf Mgf
171024-JCWPepEluC1RB5701FluIP170928P118uLinject-Monashmethod-Monashgradient.wiff Wiff
171024-JCWPepEluC1RB5701FluIP170928P118uLinject-Monashmethod-Monashgradient.wiff.scan Wiff
171024-JCWPepEluC1RB5701FluIP170928P18uLinject-Monashmethod-Monashgradient.mgf Mgf
171024-JCWPepEluC1RB5701FluIP170928P18uLinject-Monashmethod-Monashgradient.wiff Wiff
Items per page:
1 - 5 of 195
altmetric image

Publications

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation.

Waddington James C JC   Meng Xiaoli X   Illing Patricia T PT   Tailor Arun A   Adair Kareena K   Whitaker Paul P   Hamlett Jane J   Jenkins Rosalind E RE   Farrell John J   Berry Neil N   Purcell Anthony W AW   Naisbitt Dean J DJ   Park Brian Kevin BK  

Toxicological sciences : an official journal of the Society of Toxicology 20201001 2

Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver reactions. Although expression of human leukocyte antigen (HLA)-B*57:01 increases susceptibility, little is known of the pathological mechanisms involved in the induction of the clinical phenotype. Irreversible protein modification is suspected to drive the reaction through the modification of peptides that are presented by the risk allele. In this study, the binding of flucloxacillin to immune cells w  ...[more]

Similar Datasets

Proteomics HLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
2017-02-13 | PXD005502 | Pride
Proteomics A novel microprotein HDSP encoded by HOXA10-HOXA9 triggers progression of gastric cancer through maintaining the stability of MECOM and activating MECOM /SPINK1-/EGFR signaling
2024-06-18 | PXD053200 | Pride
Proteomics MHC peptides presentation is limited by availability of empty HLA molecules rather than the supply of peptides ligands
2018-05-10 | PXD007596 | Pride
Other The landscape of the SARS-CoV-2 HLA-peptidome
2021-09-10 | PXD023614 | Pride
Proteomics The landscape of the SARS-CoV-2 HLA-peptidome
2021-06-28 | PXD025499 | Pride
Proteomics MHCI peptidome of HepG2 with ArgRS or SRRM2 knock down
2023-04-14 | PXD036232 | Pride
Proteomics C1R.A*01:01, C1R.A*02:01, C1R.A*24:02 MHC class I immunopeptidome LC-MSMS
2020-07-27 | PXD014754 | Pride
Proteomics,Multiomics Pervasive functional micropeptides in humans encoded by non-canonical open reading frames
2020-03-06 | PXD014031 | Pride
Proteomics Impacts of HLA-B57 micropolymorphism (MRM)
2018-10-24 | PXD009850 | Pride
Proteomics HLA-I peptidomes and phosphopeptidomes (B*40, B*27, B*07, B*39)
2016-12-12 | PXD005084 | Pride