Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung
SUBMITTER: Francois Delalande
LAB HEAD: Sarah CIANFERANI
PROVIDER: PXD020180 | Pride | 2021-09-09
REPOSITORIES: Pride
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Ghoroghi Shima S Mary Benjamin B Larnicol Annabel A Asokan Nandini N Klein Annick A Osmani Naël N Busnelli Ignacio I Delalande François F Paul Nicodème N Halary Sébastien S Gros Frédéric F Fouillen Laetitia L Haeberle Anne-Marie AM Royer Cathy C Spiegelhalter Coralie C André-Grégoire Gwennan G Mittelheisser Vincent V Detappe Alexandre A Murphy Kendelle K Timpson Paul P Carapito Raphaël R Blot-Chabaud Marcel M Gavard Julie J Carapito Christine C Vitale Nicolas N Lefebvre Olivier O Goetz Jacky G JG Hyenne Vincent V
eLife 20210106
Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obscure. Using mouse models, we show that GTPases of the Ral family control, through the phospholipase D1, multi-vesicular bodies homeostasis and tune the biogenesis and secretion of pro-metastatic EVs. Importantly, EVs from RalA or RalB depleted cells ...[more]