Proteomics

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Proteomics of lung tissues from COVID19 patients

ABSTRACT: Coagulopathy is a hallmark finding in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with an increased risk of death from venous and arterial thromboembolic complications. SARS-CoV-2 infection can lead to microvascular thrombosis that contributes to acute lung injury and respiratory failure. The molecular mechanisms leading to thrombosis in Coronavirus disease 2019 (COVID19) patients are poorly understood. Here, we study a role of the procoagulant neutrophil extracellular traps (NETs)/Factor XII (FXII) axis in COVID19-associated thromboembolism.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Christoph Krisp  

LAB HEAD: Maike Frye

PROVIDER: PXD020216 | Pride | 2021-08-20

REPOSITORIES: Pride

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206011_CK_MF_321_DDA.mzML Mzml
206011_CK_MF_321_DDA.raw Raw
206011_CK_MF_327_DDA.mzML Mzml
206011_CK_MF_327_DDA.raw Raw
206011_CK_MF_360_DDA.mzML Mzml
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Publications

<h4>Background</h4>Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 disease. The mechanisms that drive thrombo-inflammation in COVID-19 are poorly understood.<h4>Methods</h4>We performed proteomic analysis and immunostaining of postmortem lung tissues from COVID-19 patients and patients with other lung pathologies  ...[more]

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