Proteomics

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Affinity purification mass spectrometry analysis of SARS-CoV-2 and SARS-CoV proteins in A549 cells

ABSTRACT: To determine the cellular binding partners of SARS-CoV-2 and SARS-CoV, A459 cells were transduced with lentiviruses expressing HA-tagged virus proteins and subjected to affinity purification mass spectrometry analysis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Christian Urban  

LAB HEAD: Andreas Pichlmair

PROVIDER: PXD020222 | Pride | 2020-07-14

REPOSITORIES: Pride

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Publications

The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology<sup>1-10</sup>. Integration of such datasets to obtain a holistic view of virus-host interactions and to define the pathogenic properties of SARS-CoV-2 is limited by the heterogeneity of the experimental systems. He  ...[more]

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