Proteomics

Dataset Information

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Genome- and proteome-wide analysis of lysine acetylation in Vibrio vulnificus Vv180806 reveals its regulatory roles in virulence and antibiotic resistance


ABSTRACT: V. vulnificus is an emergent pathogen and causes deadly septicemia in human. Protein acetylation regulates many important biological processes in bacteria. In this study, we identified the first lysine acetylome of V. vulnificus based on the whole-genome sequence of a cefoxitin-resistant strain isolated from a mortality case in China. A total of 6,626 acetylation sites at 1,924 acetylated proteins were uncovered, which to our knowledge represented the largest acetylated protein number that has been identified in bacteria. The presence of acetylation sites in virulence- and antibiotic resistance-related proteins further indicated the important role of acetylated modification on bacterial virulence and antibiotic resistance. Further investigation on the regulatory mechanisms will provide a better understanding of pathogen-host interactions in this increasingly pathogen.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Vibrio Vulnificus Vv

SUBMITTER: Rui Pang  

LAB HEAD: Rui Pang

PROVIDER: PXD020376 | Pride | 2020-12-01

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
C9214PIAc_Vv_1_fr1.raw Raw
C9214PIAc_Vv_1_fr2.raw Raw
C9214PIAc_Vv_1_fr3.raw Raw
C9214PIAc_Vv_1_fr4.raw Raw
C9214PIAc_Vv_1_mqpar.xml Xml
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Publications

Genome- and Proteome-Wide Analysis of Lysine Acetylation in <i>Vibrio vulnificus</i> Vv180806 Reveals Its Regulatory Roles in Virulence and Antibiotic Resistance.

Pang Rui R   Li Ying Y   Liao Kang K   Guo Penghao P   Li Yanping Y   Yang Xiaojuan X   Zhang Shuhong S   Lei Tao T   Wang Juan J   Chen Moutong M   Wu Shi S   Xue Liang L   Wu Qingping Q  

Frontiers in microbiology 20201105


Infection with <i>Vibrio vulnificus</i> is notorious for its atypical clinical manifestations and irreversible disease progression. Lysine acetylation is a conserved post-translational modification (PTM) that plays a critical regulatory role in diverse cellular processes. However, little is known about the role of lysine acetylation on the pathogenesis of <i>V. vulnificus</i>. Here, we report the complete genome sequence and a global profile for protein lysine acetylation of <i>V. vulnificus</i>  ...[more]

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