Proteomics

Dataset Information

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Proteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines:extracellular vesicles only


ABSTRACT: The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screening of predictive biomarkers. We have performed label-free mass spectrometric profiling of extracellular vesicles originated from human colon cancer cell lines Caco-2, HT-26 and HCT-116, and from lung cancer cell lines NCI-H23 and A549.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer,Non-small Cell Lung Carcinoma

SUBMITTER: Svetlana Novikova  

LAB HEAD: Victor Zgoda

PROVIDER: PXD020467 | Pride | 2021-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
A549_exo1_r1.raw Raw
A549_exo1_r2.raw Raw
A549_exo1_r3.raw Raw
A549_exo2_r1.raw Raw
A549_exo2_r2.raw Raw
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Publications

Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.

Novikova Svetlana S   Shushkova Natalia N   Farafonova Tatiana T   Tikhonova Olga O   Kamyshinsky Roman R   Zgoda Victor V  

International journal of molecular sciences 20200909 18


Tumor-derived extracellular vesicles (EVs), including exosomes, contain proteins that mirror the molecular landscape of producer cells. Being potentially detectible in biological fluids, EVs are of great interest for the screening of cancer biomarkers. To reveal universal, tissue-specific, and line-specific markers, we performed label-free mass spectrometric profiling of EVs originating from the human colon cancer cell lines Caco-2, HT29, and HCT-116, as well as from the lung cancer cell lines N  ...[more]

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