Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF, Q TRAP
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: Christoph Schlaffner
LAB HEAD: Judith A. Steen
PROVIDER: PXD020482 | Pride | 2020-12-04
REPOSITORIES: Pride
Action | DRS | |||
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FLEXITau_MC1.sky | Other | |||
FLEXITau_MC1.sky.view | Other | |||
FLEXITau_MC1.skyd | Other | |||
MaxQuant_MC1.zip | Other | |||
PHF316_MC1.raw | Raw |
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Wesseling Hendrik H Mair Waltraud W Kumar Mukesh M Schlaffner Christoph N CN Tang Shaojun S Beerepoot Pieter P Fatou Benoit B Guise Amanda J AJ Cheng Long L Takeda Shuko S Muntel Jan J Rotunno Melissa S MS Dujardin Simon S Davies Peter P Kosik Kenneth S KS Miller Bruce L BL Berretta Sabina S Hedreen John C JC Grinberg Lea T LT Seeley William W WW Hyman Bradley T BT Steen Hanno H Steen Judith A JA
Cell 20201113 6
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of 95 PTMs on multiple isoforms of Tau isolated from postmortem human tissue from 49 AD and 42 control subjects. Although Tau PTM maps reveal heterogeneity across subjects, a subset of PTMs display high occupancy and frequency for AD, suggesting importance in disease. Unsupervised analyses indicate that PTMs occur in ...[more]