Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Babal jha
LAB HEAD: Babal K Jha
PROVIDER: PXD020550 | Pride | 2020-09-09
REPOSITORIES: Pride
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19oct1014-1.msf | Msf | |||
19oct1014.raw | Raw | |||
19oct1015-1.msf | Msf | |||
19oct1015.raw | Raw | |||
19oct1017-1.msf | Msf |
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Guan Yihong Y Greenberg Edward F EF Hasipek Metis M Chen Shi S Liu Xiaochen X Kerr Cassandra M CM Gackowski Daniel D Zarakowska Ewelina E Radivoyevitch Tomas T Gu Xiaorong X Willard Belinda B Visconte Valeria V Makishima Hideki H Nazha Aziz A Mukherji Mridul M Sekeres Mikkael A MA Saunthararajah Yogen Y Oliński Ryszard R Xu Mingjiang M Maciejewski Jaroslaw P JP Jha Babal K BK
Communications biology 20200907 1
Loss-of-function TET2 mutations (TET2<sup>MT</sup>) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2<sup>MT</sup> thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA) increases dioxygenase activity by facilitating Fe(III)/Fe(II) redox reaction and may alleviate some biological consequences of TET2<sup>MT</sup> by restoring dioxygenase activity. Here, we report the utility of AA in the prev ...[more]