Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Rupert Mayer
LAB HEAD: Peter Vangheluwe
PROVIDER: PXD020559 | Pride | 2020-12-09
REPOSITORIES: Pride
Action | DRS | |||
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ATP13A1.fasta | Fasta | |||
ATP13A2.fasta | Fasta | |||
ATP13A3.fasta | Fasta | |||
ATP13A4.fasta | Fasta | |||
CHO_20190905_23885seq.fasta | Fasta |
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The Journal of biological chemistry 20201217
Polyamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but the transporters responsible for their uptake in mammalian cells remain poorly characterized. Here, we reveal a new component of the mammalian polyamine transport system using CHO-MG cells, a widely used model to study alternative polyamine uptake routes and characterize polyamine transport inhibitors for therapy. CHO-MG cells present polyamine uptake deficiency and resistance to a toxic poly ...[more]