Proteomics

Dataset Information

0

ATR interactome in Homo sapiens bone osteosarcoma U2OS cells


ABSTRACT: MS experiments for ATR interactors (GFP-ATR pull-down):SILAC 1,SILAC 2, SILAC 3

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: vittoria matafora  

LAB HEAD: Angela Bachi

PROVIDER: PXD020622 | Pride | 2020-09-30

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
UR234_A1.raw Raw
UR234_A10.raw Raw
UR234_A10bis.raw Raw
UR234_A1bis.raw Raw
UR234_A2.raw Raw
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Publications


ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy, electron microscopic analysis, biophysical and in vivo models, we report that ATR-defective cells exhibit altered nuclear plasticity and YAP delocalization. When subjected to mechanical stress or undergoing interstitial migration, ATR-defective nuclei collapse accumulating nuclear envelope ruptures and perinuclear cGAS, which indicate loss  ...[more]

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