Dataset Information

Cell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice

ABSTRACT: Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effects of IL-6 type cytokines. We therefore generated mouse models for liver cell type-specific analysis of IL-6 signalling.

INSTRUMENT(S): Orbitrap Fusion, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma, Liver

SUBMITTER: Christoph Krisp

LAB HEAD: Dirk Schmidt-Arras

PROVIDER: PXD020744 | Pride | 2021-08-20

REPOSITORIES: Pride

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Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.

Schumacher Neele N Yan Karsten K Gandraß Monja M Müller Miryam M Krisp Christoph C Häsler Robert R Carambia Antonella A Nofer Jerzy-Roch JR Bernardes Joanna P JP Khouja Mouhamad M Thomsen Ilka I Chalupsky Karel K Bolik Julia J Hölscher Christoph C Wunderlich Thomas T Herkel Johannes J Rosenstiel Philip P Schramm Christoph C Schlüter Hartmut H Renné Thomas T Mittrücker Hans-Willi HW Rose-John Stefan S Schmidt-Arras Dirk D

Journal of hepatology 20200925 2

<h4>Background & aims</h4>Interleukin (IL)-6 cytokine family members contribute to inflammatory and regenerative processes. Engagement of the signaling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6-type cytokines, making it difficult to delineate cell type-specific effects. We therefore generated mouse models for liver cell type-specific analysis of IL-6 signaling.<h4>Methods</h4>We produced mice with a Cre-inducible expr ...[more]

PMID: 32987028

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			Action	DRS
	181011_CK_NS_Liver.pdResult	Other
	181011_Liver_186.mzML	Mzml
	181011_Liver_186.raw	Raw
	181011_Liver_187.mzML	Mzml
	181011_Liver_187.raw	Raw