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Exercise Proteomics LPC mouse models

ABSTRACT: Exercise has the potential to significantly impact those suffering from autoimmune and inflammatory diseases including multiple sclerosis (MS). However, persons with multiple sclerosis (PwMS) do not engage in sufficient activity due to barriers such as increased fatigue, reduced mobility and disability. Characterizing the potential molecular benefits for acute exercise is critical for understanding its therapeutic effects on inflammatory lesions. Investigating the effects of exercise on the central nervous system (CNS) will help in guiding future design and implementation of programs to maximize the benefits of exercise for PwMS.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Cell, Spinal Cord, Blood Serum

DISEASE(S): Multiple Sclerosis

SUBMITTER: Antoine Dufour

LAB HEAD: Antoine Dufour Lab

PROVIDER: PXD020782 | Pride | 2020-08-11

REPOSITORIES: Pride

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			Action	DRS
	S9723_TD_MC_Sera_1_190815.raw	Raw
	S9724_TD_MC_Sera_2_190815.raw	Raw
	S9725_TD_MC_Sera_3_190815.raw	Raw
	S9726_TD_MC_Tissue_1_190815.raw	Raw
	S9727_TD_MC_Tissue_2_190815.raw	Raw

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Project description:Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC assigned sequentially to exercise (n = 15) and non-exercise (n = 10) groups. Individuals with no PCC served as a control group. The exercise program included cardiovascular and resistance exercises. Physical capacity, physical activity level and the presence of common PCC symptoms were measured before and after the intervention. Fatigue was measured the day following each exercise session. Plasma and PBMC samples were collected at the beginning and end of the training program. Glutathione and deoxyguanosine levels in PBMC and plasma proteomic profiles were evaluated. Results: Bicep Curl (p=0.040) and STS-30 (p=0.043) improved to a greater extent in the exercise group than in the non-exercise group. An interaction effect was also observed for the level of physical activity (p=0.007) with a positive effect of the program on their daily functioning and without any adverse effects on general or post-effort fatigue. Glutathione levels showed marked improvement after exercise. Discernable changes were observed in the plasma proteomics profile with certain proteins involved in inflammatory response (SA100A8) decreasing in the exercise group. Conclusion: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.

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Exercise Proteomics LPC mouse models

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