Dataset Information

Characterization of Plasmodium falciparum NEDD8

ABSTRACT: Here, we characterize the Plasmodium falciparum NEDD8 and demonstrate that P. falciparum cullins are NEDD8 substrates. This work lays the foundation for understanding the role of protein neddylation in malaria parasites.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Navin Adhikari

LAB HEAD: Puran Singh Sijwali

PROVIDER: PXD020885 | Pride | 2021-06-08

REPOSITORIES: Pride

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Characterization of Plasmodium falciparum NEDD8 and identification of cullins as its substrates.

Bhattacharjee Manish M Adhikari Navin N Sudhakar Renu R Rizvi Zeba Z Das Divya D Palanimurugan R R Sijwali Puran Singh PS

Scientific reports 20201119 1

A variety of post-translational modifications of Plasmodium falciparum proteins, including phosphorylation and ubiquitination, are shown to have key regulatory roles during parasite development. NEDD8 is a ubiquitin-like modifier of cullin-RING E3 ubiquitin ligases, which regulates diverse cellular processes. Although neddylation is conserved in eukaryotes, it is yet to be characterized in Plasmodium and related apicomplexan parasites. We characterized P. falciparum NEDD8 (PfNEDD8) and identifie ...[more]

PMID: 33214620

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			Action	DRS
	WTmock2Exp2.msf	Msf
	WTmockA2Exp2.raw	Raw
	WTmockAExp1.raw	Raw
	WTmockAExp2.raw	Raw
	WTmockAExp3.raw	Raw