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Proteomics of induced senescent cells

ABSTRACT: OMI (Uniprot ID O43464) is a pro-apoptotic protease localized to the mitochondria which was hypothesized to activate senescense following X-ray irradiation via cleavage of specific ligands. To elucidate cellular processes affected by OMI after irradiation, human lung cancer cell line was subjected to the following treatments: WT + X-ray irradiation WT - X-ray irradiation WT + OMI-inhibitor + X-ray irradiation WT + OMI-inhibitor - X-ray irradiation OMI-siRNA + X-ray irradiation OMI-siRNA - X-ray irradiation siRNA-empty vector (control) + X-ray irradiation siRNA-empty vector (control) - X-ray irradiation

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Alon Savidor

LAB HEAD: Prof. Adi Kimchi

PROVIDER: PXD020972 | Pride | 2022-01-30

REPOSITORIES: Pride

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			Action	DRS
	HF1_10057_AKI_1_DMSO_-IR_F1a_110919.raw	Raw
	HF1_10057_AKI_1_DMSO_-IR_F2a_290819.raw	Raw
	HF1_10057_AKI_1_DMSO_-IR_F3a_080919.raw	Raw
	HF1_10057_AKI_1_DMSO_-IR_F4a_290819.raw	Raw
	HF1_10057_AKI_1_DMSO_-IR_F5a_050919.raw	Raw

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