Dataset Information

Hypoxia TMT Proteomics on Pancreatic Cancer Cell Lines

ABSTRACT: PDAC(pancreatic ductal adenocarcinoma) cell lines- MiaPaca and 8988T were exposed to normoxic (20% Oxygen, 2 replicates each for MiaPaca and 8988T) or Hypoxia (0.1% Oxygen,3 replicates each for MiaPaca and 8998T) for 24 hrs

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Ductal Cell, Pancreatic Ductal Adenocarcinoma Cell Line

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Vinay Eapen

LAB HEAD: Joseph Mancias

PROVIDER: PXD020990 | Pride | 2020-10-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	316173_JM03943TMT10_HypoxiaTMT10_Hypoxia.mzIdentML	Mzid
	316174_JM03944TMT10_HypoxiaTMT10_Hypoxia.mzIdentML	Mzid
	316175_JM03945TMT10_HypoxiaTMT10_Hypoxia.mzIdentML	Mzid
	316176_JM03946TMT10_HypoxiaTMT10_Hypoxia.mzIdentML	Mzid
	316177_JM03947TMT10_HypoxiaTMT10_Hypoxia.mzIdentML	Mzid

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Publications

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer.

Hollinshead Kate E R KER Parker Seth J SJ Eapen Vinay V VV Encarnacion-Rosado Joel J Sohn Albert A Oncu Tugba T Cammer Michael M Mancias Joseph D JD Kimmelman Alec C AC

Cell reports 20201001 1

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that contributes to its aggressiveness, therapeutic resistance, and high mortality. Despite oxygen being a fundamental requirement for many cellular and metabolic processes, and the severity of hypoxia in PDAC, the impact of oxygen deprivation on PDAC biology is poorly understood. Investigating how PDAC cells survive in the near absenc ...[more]

PMID: 33027658

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