Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Jie Luo
LAB HEAD: Jeff Ranish
PROVIDER: PXD020992 | Pride | 2021-02-10
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
BAF-NCP.inter1.xls | Xls | |||
BAF-NCP.intra1.xls | Xls | |||
JL021919_030919_BAF_NCP_sp3.mzXML | Mzxml | |||
JL021919_030919_BAF_NCP_sp3_100B.mzXML | Mzxml | |||
JL021919_030919_BAF_NCP_sp3_30B.mzXML | Mzxml |
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Cell 20201013 3
Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that regulate genomic architecture. Here, we present a structural model of the endogenously purified human canonical BAF complex bound to the nucleosome, generated using cryoelectron microscopy (cryo-EM), cross-linking mass spectrometry, and homology modeling. BAF complexes bilaterally engage the nucleosome H2A/H2B acidic patch regions through the SMARCB1 C-terminal α-helix and the SMARCA4/2 C-terminal SnAc/post-SnAc re ...[more]