Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart
DISEASE(S): Covid-19
SUBMITTER: Sean Humphrey
LAB HEAD: Sean Humphrey
PROVIDER: PXD020994 | Pride | 2022-02-21
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 7 |
Mills Richard J RJ Humphrey Sean J SJ Fortuna Patrick R J PRJ Lor Mary M Foster Simon R SR Quaife-Ryan Gregory A GA Johnston Rebecca L RL Dumenil Troy T Bishop Cameron C Rudraraju Rajeev R Rawle Daniel J DJ Le Thuy T Zhao Wei W Lee Leo L Mackenzie-Kludas Charley C Mehdiabadi Neda R NR Halliday Christopher C Gilham Dean D Fu Li L Nicholls Stephen J SJ Johansson Jan J Sweeney Michael M Wong Norman C W NCW Kulikowski Ewelina E Sokolowski Kamil A KA Tse Brian W C BWC Devilée Lynn L Voges Holly K HK Reynolds Liam T LT Krumeich Sophie S Mathieson Ellen E Abu-Bonsrah Dad D Karavendzas Kathy K Griffen Brendan B Titmarsh Drew D Elliott David A DA McMahon James J Suhrbier Andreas A Subbarao Kanta K Porrello Enzo R ER Smyth Mark J MJ Engwerda Christian R CR MacDonald Kelli P A KPA Bald Tobias T James David E DE Hudson James E JE
Cell 20210316 8
Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be through direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms and cardio-protective drugs, we use a state-of-the-art pipeline combining human cardiac organoids with phosphoproteomics and single nuclei RNA sequencing. We identify an inflammatory "cytokine-storm", a cocktail of interferon gamma, interleukin 1β, and poly(I:C), induced d ...[more]