Loss of adipose triglyceride lipase aids cancer growth in 3D
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Gallus Gallus (chicken)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: 
Sophie Honeder
LAB HEAD: Ruth Birner-Gruenberger
PROVIDER: PXD021105 | Pride | 2021-05-21
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 3DCAM_mzTab.mzTab.gz | Mztab | |||
| 3DCAM_txt.zip | Other | |||
| 3D_2D_onCAM_1.6.14.0.xml | Xml | |||
| 3D_mzTab.mzTab.gz | Mztab | |||
| 3D_txt.zip | Other |
Items per page: 5 1 - 5 of 452 |
Publications
Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids.
Honeder Sophie S Tomin Tamara T Nebel Laura L Gindlhuber Jürgen J Fritz-Wallace Katarina K Schinagl Maximilian M Heininger Christoph C Schittmayer Matthias M Ghaffari-Tabrizi-Wizsy Nassim N Birner-Gruenberger Ruth R
Molecular & cellular proteomics : MCP 20210514
Cancer cells undergo complex metabolic adaptations to survive and thrive in challenging environments. This is particularly prominent for solid tumors, where cells in the core of the tumor are under severe hypoxia and nutrient deprivation. However, such conditions are often not recapitulated in the typical 2D in vitro cancer models, where oxygen as well as nutrient exposure is quite uniform. The aim of this study was to investigate the role of a key neutral lipid hydrolase, namely adipose triglyc ...[more]
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