Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Hee Jong Kim
LAB HEAD: Benjamin Aaron Garcia
PROVIDER: PXD021212 | Pride | 2021-07-07
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 14 |
van Eeuwen Trevor T Shim Yoonjung Y Kim Hee Jong HJ Zhao Tingting T Basu Shrabani S Garcia Benjamin A BA Kaplan Craig D CD Min Jung-Hyun JH Murakami Kenji K
Nature communications 20210607 1
The versatile nucleotide excision repair (NER) pathway initiates as the XPC-RAD23B-CETN2 complex first recognizes DNA lesions from the genomic DNA and recruits the general transcription factor complex, TFIIH, for subsequent lesion verification. Here, we present a cryo-EM structure of an NER initiation complex containing Rad4-Rad23-Rad33 (yeast homologue of XPC-RAD23B-CETN2) and 7-subunit coreTFIIH assembled on a carcinogen-DNA adduct lesion at 3.9-9.2 Å resolution. A ~30-bp DNA duplex could be m ...[more]