Proteomics

Dataset Information

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Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome


ABSTRACT: We measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Victor Faundez  

LAB HEAD: Victor Faundez

PROVIDER: PXD021473 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

FMRP attenuates activity dependent modifications in the mitochondrial proteome.

Bülow Pernille P   Zlatic Stephanie A SA   Wenner Peter A PA   Bassell Gary J GJ   Faundez Victor V  

Molecular brain 20210430 1


Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported that homeostatic plasticity induced by activity deprivation is dysregulated in cortical neurons from Fragile X Mental Retardation protein (FMRP) knockout mice (Bulow et al. in Cell Rep 26: 1378-1388 e1373, 2019). These findings led us to hypothesize that identif  ...[more]

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