Dataset Information

Proteomics analysis of islets of 6-week old NOR and NOD mice

ABSTRACT: Islets from 6-week old NOR and NOD mice were submitted to proteomics analysis to study differences in insulitis and type 1 diabetes development.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Islet

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Ernesto Nakayasu

LAB HEAD: Ernesto Nakayasu

PROVIDER: PXD021475 | Pride | 2024-05-21

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	SCR_NOD_M1_320islets_01_3hrQE_27Jun16_Arwen_16-03-40.raw	Raw
	SCR_NOD_M2_340islets_02_3hrQE_27Jun16_Arwen_16-03-40.raw	Raw
	SCR_NOD_M3_400islets_03_3hrQE_27Jun16_Arwen_16-03-40.raw	Raw
	SCR_WT_M1_320islets_04_3hrQE_27Jun16_Arwen_16-03-40.raw	Raw
	SCR_WT_M2_520islets_05_3hrQE_27Jun16_Arwen_16-03-40.raw	Raw

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1 - 5 of 9

Publications

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis.

Sarkar Soumyadeep S Deiter Cailin C Kyle Jennifer E JE Guney Michelle A MA Sarbaugh Dylan D Yin Ruichuan R Li Xiangtang X Cui Yi Y Ramos-Rodriguez Mireia M Nicora Carrie D CD Syed Farooq F Juan-Mateu Jonas J Muralidharan Charanya C Pasquali Lorenzo L Evans-Molina Carmella C Eizirik Decio L DL Webb-Robertson Bobbie-Jo M BM Burnum-Johnson Kristin K Orr Galya G Laskin Julia J Metz Thomas O TO Mirmira Raghavendra G RG Sussel Lori L Ansong Charles C Nakayasu Ernesto S ES

Cell communication and signaling : CCS 20240221 1

<h4>Background</h4>Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death.<h4>Methods</h4>We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabetic non-obese mice. We also perfo ...[more]

PMID: 38383396

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