Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mycoplasma Pneumoniae (strain Atcc 29342 / M129)
SUBMITTER: Marc Weber
LAB HEAD: Luis Serrano
PROVIDER: PXD021506 | Pride | 2020-11-24
REPOSITORIES: Pride
Action | DRS | |||
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2020MM006_RABU_001_02_1ug.msf | Msf | |||
2020MM006_RABU_001_02_1ug.raw | Raw | |||
2020MM006_RABU_002_01_1ug.raw | Raw | |||
2020MM006_RABU_003_01_1ug.raw | Raw | |||
2020MM006_RABU_004_01_1ug.raw | Raw |
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Molecular systems biology 20201201 12
Protein degradation is a crucial cellular process in all-living systems. Here, using Mycoplasma pneumoniae as a model organism, we defined the minimal protein degradation machinery required to maintain proteome homeostasis. Then, we conditionally depleted the two essential ATP-dependent proteases. Whereas depletion of Lon results in increased protein aggregation and decreased heat tolerance, FtsH depletion induces cell membrane damage, suggesting a role in quality control of membrane proteins. A ...[more]