Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Peripheral Primitive Neuroectodermal Tumor
SUBMITTER: Joanna Kirkpatrick
LAB HEAD: Zhao-Qi Wang
PROVIDER: PXD021562 | Pride | 2021-09-09
REPOSITORIES: Pride
Action | DRS | |||
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190802_EKS_CM_DDA_AUY922VE821_15.raw | Raw | |||
190802_EKS_CM_DDA_AUY922_5.raw | Raw | |||
190802_EKS_CM_DDA_VE821_11.raw | Raw | |||
190802_EKS_CM_DDA_ctrl_1.raw | Raw | |||
190802_EKS_CM_DIA_AUY922VE821_13.raw | Raw |
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Cell & bioscience 20210320 1
<h4>Introduction</h4>Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the ATR inhibitor VE821 or the ATM inhibitor KU55933 were investigated for their effectiveness in Ewing's sarcoma cells.<h4>Methods</h4>Effects were determined in p53 wild-type and p53 null Ewing's sarcoma cell lines by flow cytometric analyses of cell death, mitochondrial ...[more]