Dataset Information

Brain proteome analysis in Alzheimer's disease

ABSTRACT: Analysis of region-dependent fluctuations on a proteome-wide scale, performing integrative analysis of the proteome and phosphoproteome across AD stages in EC and FC.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD021653 | Pride | 2022-02-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	ADI-II_019-206-CortezaFrontalFC-18.wiff	Wiff
	ADI-II_019-206-CortezaFrontalFC-18.wiff.scan	Wiff
	ADI-II_019-206-CortezaFrontalFC-Phospho-18.wiff	Wiff
	ADI-II_019-206-CortezaFrontalFC-Phospho-18.wiff.scan	Wiff
	ADI-II_025-206-CortezaFrontalFC-14.wiff	Wiff

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Publications

Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease.

Ferrer Isidro I Andrés-Benito Pol P Ausín Karina K Pamplona Reinald R Del Rio José Antonio JA Fernández-Irigoyen Joaquín J Santamaría Enrique E

Brain pathology (Zurich, Switzerland) 20210704 6

Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as stages I-II, III-IV, and V-VI without comorbidities, and of middle-aged (MA) individuals with no NFT pathology, were analyzed by conventional label-free and SWATH-MS (sequential window acquisition of all theoretical fragment ion spectra mass spectrometry) to assess the (phospho)pr ...[more]

PMID: 34218486

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