Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Greg Wang
LAB HEAD: Greg Wang
PROVIDER: PXD021679 | Pride | 2020-11-05
REPOSITORIES: Pride
Action | DRS | |||
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PC291_control_1.msf | Msf | |||
PC291_control_1.raw | Raw | |||
PC291_control_2.msf | Msf | |||
PC291_control_2.raw | Raw | |||
PC291_sample_1.msf | Msf |
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Fan Huitao H Lu Jiuwei J Guo Yiran Y Li Dongxu D Zhang Zhi-Min ZM Tsai Yi-Hsuan YH Pi Wen-Chieh WC Ahn Jeong Hyun JH Gong Weida W Xiang Yu Y Allison David F DF Geng Huimin H He Shenghui S Diao Yarui Y Chen Wei-Yi WY Strahl Brian D BD Cai Ling L Song Jikui J Wang Gang Greg GG
Nature genetics 20201102 12
Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation. We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1 (BAHCC1<sup>BAH</sup>) 'recognizes' H3K27me3 specifically and enforces silencing of H3K27me3-demarcated genes in mammalian cells. Biochemical, structural and integrated chromatin immunoprecipitation-sequencing-based analyses demonstrate that direct readout of H3K27me3 by BAHCC1 is achieved through a hydroph ...[more]