Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Rattus Rattus (black Rat)
SUBMITTER: Hossein Fazelinia
LAB HEAD: Serge Przedborski
PROVIDER: PXD021773 | Pride | 2021-09-09
REPOSITORIES: Pride
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Mishra Vartika V Re Diane B DB Le Verche Virginia V Alvarez Mariano J MJ Vasciaveo Alessandro A Jacquier Arnaud A Doulias Paschalis-Tomas PT Greco Todd M TM Nizzardo Monica M Papadimitriou Dimitra D Nagata Tetsuya T Rinchetti Paola P Perez-Torres Eduardo J EJ Politi Kristin A KA Ikiz Burcin B Clare Kevin K Than Manuel E ME Corti Stefania S Ischiropoulos Harry H Lotti Francesco F Califano Andrea A Przedborski Serge S
Nature communications 20201104 1
Cell-to-cell communications are critical determinants of pathophysiological phenotypes, but methodologies for their systematic elucidation are lacking. Herein, we propose an approach for the Systematic Elucidation and Assessment of Regulatory Cell-to-cell Interaction Networks (SEARCHIN) to identify ligand-mediated interactions between distinct cellular compartments. To test this approach, we selected a model of amyotrophic lateral sclerosis (ALS), in which astrocytes expressing mutant superoxide ...[more]