Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Oral Cancer Cell
SUBMITTER: Kevin Klann
LAB HEAD: Christian Münch
PROVIDER: PXD021835 | Pride | 2022-06-23
REPOSITORIES: Pride
Action | DRS | |||
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20200728_KKL_HD_F.msf | Msf | |||
20200728_KKL_HD_F1.raw | Raw | |||
20200728_KKL_HD_F10.raw | Raw | |||
20200728_KKL_HD_F11.raw | Raw | |||
20200728_KKL_HD_F12.raw | Raw |
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Nature 20220629 7919
Aggressive and metastatic cancers show enhanced metabolic plasticity<sup>1</sup>, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications-5-methylcytosine (m<sup>5</sup>C) and its derivative 5-formylcytosine (f<sup>5</sup>C) (refs.<sup>2-4</sup>)-drive the translation of mitochondrial mRNA to power metastasis. Translation of mitochondrially encoded subunits of the oxidative phosphorylation complex dep ...[more]