Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
SUBMITTER: Dupuy Jean-William
LAB HEAD: Pierre Merville
PROVIDER: PXD021852 | Pride | 2022-04-04
REPOSITORIES: Pride
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F006208.dat | Other | |||
F006209.dat | Other | |||
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F006214.dat | Other | |||
F006215.dat | Other |
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Chauveau Bertrand B Raymond Anne-Aurélie AA Di Tommaso Sylvaine S Visentin Jonathan J Vermorel Agathe A Dugot-Senant Nathalie N Dourthe Cyril C Dupuy Jean-William JW Déchanet-Merville Julie J Duong Van Huyen Jean-Paul JP Rabant Marion M Couzi Lionel L Saltel Frédéric F Merville Pierre P
Biomedicines 20220228 3
Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplantation. Its histological hallmark is represented by lesions of glomerulitis i.e., inflammatory cells within glomeruli. Current therapies for ABMR fail to prevent chronic allograft damage i.e., transplant glomerulopathy, leading to allograft loss. We used laser microdissection of glomeruli from formalin-fixed allograft biopsies combined with mass spectrometry-based proteomics to describe the proteome m ...[more]