Proteomics

Dataset Information

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Arg-GlcNAcylation of Salmonella proteins

ABSTRACT: This project explores the impact of SseK mediated Arg-GlcNAcylation on Salmonella proteins. Using Site directed mutagenesis, MS analysis and phenotypic studies we show Arg-GlcNAcylation appears to modulate the functions of multiple salmonella enzymes. This work demonstrates effectors can have multiple roles both within host cells and bacterial pathogens themselves.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. St1489

SUBMITTER: Nichollas Scott  

LAB HEAD: Philip Hardwidge

PROVIDER: PXD021878 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Arg_glcNAc_salmonella_proteins.zip Other
Nsco_NS835_20200717_YaJL_ArgGlcNAc_Trypsin.raw Raw
Nsco_NS835_20200717_YaJL_ArgGlcNAc_lysC.raw Raw
Nsco_NS835_20200717_gloA_ArgGlcNAc_Trypsin.raw Raw
Nsco_NS835_20200717_gloA_ArgGlcNAc_lysC.raw Raw
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Publications

Arginine glycosylation enhances methylglyoxal detoxification.

El Qaidi Samir S   Scott Nichollas E NE   Hardwidge Philip R PR  

Scientific reports 20210215 1

Type III secretion system effector proteins have primarily been characterized for their interactions with host cell proteins and their ability to disrupt host signaling pathways. We are testing the hypothesis that some effectors are active within the bacterium, where they modulate bacterial signal transduction and physiology. We previously determined that the Citrobacter rodentium effector NleB possesses an intra-bacterial glycosyltransferase activity that increases glutathione synthetase activi  ...[more]

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