Dataset Information

Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine

ABSTRACT: Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative proteomic approach was employed in the hippocampus of rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression, with or without chronic antidepressant tianeptine (Tian) treatment (last 3 weeks of CSIS).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain, Electrically Active Cell

DISEASE(S): Major Depressive Disorder

SUBMITTER: Victor Costina

LAB HEAD: Prof. Dr. Peter Findeisen

PROVIDER: PXD021920 | Pride | 2022-02-16

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Hippo_Synaptosol_control_1.msf	Msf
	Hippo_Synaptosol_control_1.zip	Other
	Hippo_Synaptosol_control_2.msf	Msf
	Hippo_Synaptosol_control_2.zip	Other
	Hippo_Synaptosol_control_3.msf	Msf

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Publications

Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats.

Perić Ivana I Costina Victor V Djordjević Snežana S Gass Peter P Findeisen Peter P Inta Dragoš D Borgwardt Stefan S Filipović Dragana D

Scientific reports 20210907 1

Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of action is unknown. We conducted a proteomic study on the hippocampal synaptosomal fractions of adult male Wistar rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression and after ...[more]

PMID: 34493757

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