Proteomics

Dataset Information

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Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine


ABSTRACT: Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative proteomic approach was employed in the hippocampus of rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression, with or without chronic antidepressant tianeptine (Tian) treatment (last 3 weeks of CSIS).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain, Electrically Active Cell

DISEASE(S): Major Depressive Disorder

SUBMITTER: Victor Costina  

LAB HEAD: Prof. Dr. Peter Findeisen

PROVIDER: PXD021920 | Pride | 2022-02-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Hippo_Synaptosol_control_1.msf Msf
Hippo_Synaptosol_control_1.zip Other
Hippo_Synaptosol_control_2.msf Msf
Hippo_Synaptosol_control_2.zip Other
Hippo_Synaptosol_control_3.msf Msf
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Publications

Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats.

Perić Ivana I   Costina Victor V   Djordjević Snežana S   Gass Peter P   Findeisen Peter P   Inta Dragoš D   Borgwardt Stefan S   Filipović Dragana D  

Scientific reports 20210907 1


Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of action is unknown. We conducted a proteomic study on the hippocampal synaptosomal fractions of adult male Wistar rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression and after  ...[more]

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