Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain, Electrically Active Cell
DISEASE(S): Major Depressive Disorder
SUBMITTER: Victor Costina
LAB HEAD: Prof. Dr. Peter Findeisen
PROVIDER: PXD021920 | Pride | 2022-02-16
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Hippo_Synaptosol_control_1.msf | Msf | |||
Hippo_Synaptosol_control_1.zip | Other | |||
Hippo_Synaptosol_control_2.msf | Msf | |||
Hippo_Synaptosol_control_2.zip | Other | |||
Hippo_Synaptosol_control_3.msf | Msf |
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Perić Ivana I Costina Victor V Djordjević Snežana S Gass Peter P Findeisen Peter P Inta Dragoš D Borgwardt Stefan S Filipović Dragana D
Scientific reports 20210907 1
Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of action is unknown. We conducted a proteomic study on the hippocampal synaptosomal fractions of adult male Wistar rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression and after ...[more]