Proteomics

Dataset Information

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Chromophobe renal cell carcinoma versus renal oncocytoma: a proteomic approach


ABSTRACT: The proteome of clinical tissue samples diagnosed with chromophobe renal cell carcinomas (chRCC) and renal oncocytomas (RO) were evaluated to establish a potential discriminative biomarker panel of proteins for these two tumors subtypes.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

DISEASE(S): Chromophobe Renal Cell Carcinoma,Renal Oncocytoma

SUBMITTER: Hugo M. Santos  

LAB HEAD: Hugo M. Santos

PROVIDER: PXD022018 | Pride | 2024-01-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
15_RCC_raw_data.zip Other
andromeda.zip Other
txt.zip Other
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Publications

Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation.

Carvalho Luis B LB   Jorge Susana S   López-Fernández Hugo H   Lodeiro Carlos C   Dhir Rajiv R   Campos Pinheiro Luis L   Medeiros Mariana M   Santos Hugo M HM   Capelo José L JL  

Clinical proteomics 20231128 1


<h4>Background</h4>This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), two subtypes of renal cell carcinoma that together account for approximately 10% of all renal tumors. Despite their histological similarities and shared origins, chRCC is a malignant tumor necessitating aggressive intervention, while RO, a benign growth, is often subject to overtreatment due to difficulties in accurate differentiation.<h4>Methods</h4>We cond  ...[more]

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