Epithelial to mesenchymal transition shed microvesicle proteome
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ABSTRACT: Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. EMT is associated with increased aggressiveness, invasiveness, and metastatic potential in carcinoma cells. To assess the contribution of extracellular vesicles following EMT, we conducted a proteomic analysis of shed microvesicles released from Madin-Darby canine kidney (MDCK) cells, and MDCK cells transformed with oncogenic H-Ras (21D1 cells).
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Canine Papillomavirus 19
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: david greening
LAB HEAD: David Greening
PROVIDER: PXD022290 | Pride | 2021-03-18
REPOSITORIES: pride
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