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Effects of prenylcysteine oxidase 1 (PCYOX1) silencing on HepG2 cell secretome

ABSTRACT: We performed a label free mass spectrometry-based proteomic analysis to investigate the effects of PCYOX1 silencing on the secretome of human HepG2 cells

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

SUBMITTER: Maura Brioschi

LAB HEAD: Cristina banfi

PROVIDER: PXD022302 | Pride | 2021-10-12

REPOSITORIES: Pride

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			Action	DRS
	SHPCYOX1_secretome_HepG2.DerivedFromSearchf2ec7596-9e55-4fa4-9b46-4809e865d0eb.mgf	Mgf
	SHPCYOX1_secretome_HepG2.mzid.gz	Mzid
	exp1_sec_control_01.mzML	Mzml
	exp1_sec_control_01.zip	Other
	exp1_sec_control_02.mzML	Mzml

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Publications

Prenylcysteine oxidase 1, an emerging player in atherosclerosis.

Banfi C C Baetta R R Barbieri S S SS Brioschi M M Brioschi M M Guarino A A Ghilardi S S Sandrini L L Eligini S S Polvani G G Bergman O O Eriksson P P Tremoli E E

Communications biology 20210921 1

The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the human atherosclerotic lesions, is both synthesized locally and transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall during atherogenes ...[more]

PMID: 34548610

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