Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Colon Epithelial Cell
DISEASE(S): Colon Cancer
SUBMITTER: Lulzim Shkreta
LAB HEAD: Benoit Chabot
PROVIDER: PXD022333 | Pride | 2021-09-09
REPOSITORIES: Pride
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Sohail Muhammad M Shkreta Lulzim L Toutant Johanne J Rabea Safwat S Babeu Jean-Philippe JP Huard Caroline C Coulombe-Huntington Jasmin J Delannoy Aurélie A Placet Morgane M Geha Sameh S Gendron Fernand-Pierre FP Boudreau François F Tyers Mike M Grierson David S DS Chabot Benoit B
NAR cancer 20210525 2
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic <i>BCLAF1-L</i> splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease production of <i>BCLAF1-L</i>. While additional alternative splicing events regulated by SRSF10 are affected by GPS167/192 in HCT116 cells (e.g. in <i>MDM4, WTAP, SLK1</i> and <i>CLK1</i>), other events ...[more]