Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480, Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Dengue Virus
TISSUE(S): Hepatocyte, Cell Culture
DISEASE(S): Dengue Hemorrhagic Fever,Dengue Disease,Dengue Shock Syndrome
SUBMITTER: Jonathan Davies
LAB HEAD: Lars Plate
PROVIDER: PXD022453 | Pride | 2021-01-18
REPOSITORIES: Pride
Items per page: 1 - 5 of 65 |
Proceedings of the National Academy of Sciences of the United States of America 20210101 3
Flaviviruses, including dengue and Zika, are widespread human pathogens; however, no broadly active therapeutics exist to fight infection. Recently, remodeling of endoplasmic reticulum (ER) proteostasis by pharmacologic regulators, such as compound 147, was shown to correct pathologic ER imbalances associated with protein misfolding diseases. Here, we establish an additional activity of compound 147 as an effective host-centered antiviral agent against flaviviruses. Compound 147 reduces infectio ...[more]