Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cholangiocyte, Liver
DISEASE(S): Polycystic Liver Disease
SUBMITTER: Mikel Azkargorta
LAB HEAD: Felix Elortza
PROVIDER: PXD022571 | Pride | 2022-02-16
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 24 |
Lee-Law Pui Y PY Olaizola Paula P Caballero-Camino Francisco J FJ Izquierdo-Sanchez Laura L Rodrigues Pedro M PM Perugorria Maria J MJ Azkargorta Mikel M Elortza Felix F Martinez-Chantar Maria L ML Aspichueta Patricia P Marzioni Marco M Bujanda Luis L Drenth Joost P H JPH Banales Jesus M JM
United European gastroenterology journal 20210726 7
<h4>Background</h4>Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed that cystic cholangiocytes are characterized by endoplasmic reticulum stress and aberrant posttranslational modification (PTM) of proteins, in particular hyper-SUMOylation, that promote PLD pathobiology. Protein NEDDylation is a newly characterized PTM that modulates a p ...[more]