Proteomics

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Insights into the modes of action of tritium on zebrafish, Danio rerio, early-life stages, using proteomic analyses

ABSTRACT: Tritium is an ubiquist radionuclide which can be found in the environment due to natural and anthropogenic activities, particularly in aquatic ecosystems. In this context, tritium effects on aquatic species such as fish have to be characterized. HTO (tritiated water) effects were therefore investigated in zebrafish, Danio rerio, a common model in toxicology and ecotoxicology with a fully sequenced genome. Experiments were conducted on early life stages. Larvae were exposed to 0.4 and 4 mGy/h of HTO until 10 days post fertilization. Tritium internalization was quantified and effects were investigated using a proteomic analysis. The global analysis of the proteome was performed after protein extraction at 7 and 10 dpf on zebrafish eggs exposed from 3 hpf to 10 dpf.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)

TISSUE(S): Egg

SUBMITTER: Luc Camoin  

LAB HEAD: Luc Camoin

PROVIDER: PXD022578 | Pride | 2024-08-29

REPOSITORIES: Pride

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Insights into the modes of action of tritium on the early-life stages of zebrafish, Danio rerio, using transcriptomic and proteomic analyses.

Arcanjo Caroline C   Frelon Sandrine S   Armant Olivier O   Camoin Luc L   Audebert Stéphane S   Camilleri Virginie V   Cavalié Isabelle I   Adam-Guillermin Christelle C   Gagnaire Beatrice B  

Journal of environmental radioactivity 20230304

In the environment, populations are exposed to different kinds of ionizing radiation. Little is known about their modes of action on non-human species, and whether or not they are similar for alpha, beta and gamma radiations, considered as the reference. In this context, tritium effects (beta emitter) under the form of tritiated water (HTO) were investigated in zebrafish, a common model in toxicology and ecotoxicology with a fully sequenced genome. Experiments were conducted on early life stages  ...[more]

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