Dataset Information

Dezocine pull down LC-MSMS in MDA-MB-231 CELLS

ABSTRACT: To reveal the direct target and molecular mechanisms underlying the effects of dezocine, a pull-down assay and HPLC-MS/MS were performed.l the direct target and molecular mechanisms underlying the effects of dezocine, a pull-down assay and HPLC-MS/MS were performed.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Breast Cancer

SUBMITTER: Chenyang Xue

LAB HEAD: Duo Zheng

PROVIDER: PXD022583 | Pride | 2021-09-09

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20181018-7samples-dezjkw-14.rar	Other
	SupplementaryFigure1.tif	Other
	target_of_dezocine.xlsx	Xlsx
	zouyddezocine120181015__FDR.xlsx	Xlsx
	zouyddezocine220181015__FDR.xlsx	Xlsx

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Publications

Dezocine, An Opioid Analgesic, Exerts Antitumor Effects in Triple-Negative Breast Cancer by Targeting Nicotinamide Phosphoribosyltransferase.

Xue Chenyang C Chen Wei W Yuan Aiwu A Chen Cheng C Li Shuaihu S Chen Kai K Zhao Yang Y Xiao Tian T Shao Genze G Zou Yongdong Y Zheng Duo D

Frontiers in pharmacology 20210412

Opioids are a potential adjuvant treatment for certain cancers; while they are primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly used in China, but its effects on cancer cells are unknown. Here, we demonstrated the inhibitory effect of dezocine on triple-negative breast cancer (TNBC) cells, and determined the underlying molecular mechanism. We found that dezocine suppressed cell proliferation, migration and inva ...[more]

PMID: 33912035

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