Dataset Information

Proteomic changes in aging rats treated with the cognitive enhancer CE-123

ABSTRACT: Aging rats with cognitive decline have been behaviourally evaluated and were divided into two groups, treated with CE-123, a dopamine transporter inhibitor, and vehicle. Memory-related brain areas were dissected and following sample preparation run on q-exactive from thermo fisher. Data handling and basic bioinformatics showed interesting differences pointing to several mechanisms.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Gert Lubec

LAB HEAD: Gert Lubec

PROVIDER: PXD022737 | Pride | 2022-02-16

REPOSITORIES: Pride

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Publications

Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats.

Gyertyán István I Lubec Jana J Ernyey Alíz Judit AJ Gerner Christopher C Kassai Ferenc F Kalaba Predrag P Kozma Kata K Cobankovic Iva I Brenner Gábor G Wackerlig Judith J Franschitz Eva E Urban Ernst E Langer Thierry T Malikovic Jovana J Lubec Gert G

Scientific reports 20211214 1

The lack of novel cognitive enhancer drugs in the clinic highlights the prediction problems of animal assays. The objective of the current study was to test a putative cognitive enhancer in a rodent cognitive test system with improved translational validity and clinical predictivity. Cognitive profiling was complemented with post mortem proteomic analysis. Twenty-seven male Lister Hooded rats (26 months old) having learned several cognitive tasks were subchronically treated with S-CE-123 (CE-123 ...[more]

PMID: 34907284

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	Lubec_CE123_GE_PFC.raw	Raw
	Lubec_CE123_R50_PFC.raw	Raw
	Lubec_CE123_R51_PFC.raw	Raw
	Lubec_CE123_R52_PFC.raw	Raw
	Lubec_CE123_R53_PFC.raw	Raw