Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Gabriela Lochmanova
LAB HEAD: Zdrahal Zbynek
PROVIDER: PXD022968 | Pride | 2021-09-09
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 79 |
Giallongo Sebastiano S Lo Re Oriana O Lochmanová Gabriela G Parca Luca L Petrizzelli Francesco F Zdráhal Zbyněk Z Mazza Tommaso T Vinciguerra Manlio M
Biology 20210713 7
<b>Background:</b> Gene expression in eukaryotic cells can be governed by histone variants, which replace replication-coupled histones, conferring unique chromatin properties. MacroH2A1 is a histone H2A variant containing a domain highly similar to H2A and a large non-histone (macro) domain. MacroH2A1, in turn, is present in two alternatively exon-spliced isoforms: macroH2A1.1 and macroH2A1.2, which regulate cell plasticity and proliferation in a remarkably distinct manner. The N-terminal and th ...[more]