Proteomics

Dataset Information

0

Characterization of WN NS3 and AspN proteases


ABSTRACT: Characterization of WN NS3 protease and characterization of AspN protease with double digestion protocol

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Federico Uliana  

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD022973 | Pride | 2021-02-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
200908_QE1_mvizovisek_18.raw Raw
200908_QE1_mvizovisek_19.raw Raw
200908_QE1_mvizovisek_20.raw Raw
checksum.txt Txt
peptides-AspN.txt Txt
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Publications

Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen.

Uliana Federico F   Vizovišek Matej M   Acquasaliente Laura L   Ciuffa Rodolfo R   Fossati Andrea A   Frommelt Fabian F   Goetze Sandra S   Wollscheid Bernd B   Gstaiger Matthias M   De Filippis Vincenzo V   Auf dem Keller Ulrich U   Aebersold Ruedi R  

Nature communications 20210316 1


Proteases are among the largest protein families and critical regulators of biochemical processes like apoptosis and blood coagulation. Knowledge of proteases has been expanded by the development of proteomic approaches, however, technology for multiplexed screening of proteases within native environments is currently lacking behind. Here we introduce a simple method to profile protease activity based on isolation of protease products from native lysates using a 96FASP filter, their analysis in  ...[more]

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