Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Liver
DISEASE(S): Hepatocellular Carcinoma
SUBMITTER: Yuhan Gu
LAB HEAD: Hailing Qiao
PROVIDER: PXD023118 | Pride | 2022-02-22
REPOSITORIES: Pride
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Cell death & disease 20220208 2
Although there are many studies on the relationship between genetic polymorphisms and the incidence of diseases, mechanisms are rarely known. We report the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promotes the occurrence and progression of hepatocellular carcinoma (HCC). We found that the GG genotype at stat4 rs7574865 was a risk genotype, and STAT4 levels in serum and peritumoral tissue from HCC patients with the GG genotype were significantly high ...[more]