Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte, Liver
DISEASE(S): Disease Free
SUBMITTER: Ke Li
LAB HEAD: Jun Zhou
PROVIDER: PXD023261 | Pride | 2021-09-09
REPOSITORIES: Pride
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International journal of molecular sciences 20210807 16
Selenoprotein T (SELENOT, SelT), a thioredoxin-like enzyme, exerts an essential oxidoreductase activity in the endoplasmic reticulum. However, its precise function remains unknown. To gain more understanding of SELENOT function, a conventional global <i>Selenot</i> knockout (KO) mouse model was constructed for the first time using the CRISPR/Cas9 technique. Deletion of SELENOT caused male sterility, reduced size/body weight, lower fed and/or fasting blood glucose levels and lower fasting serum i ...[more]