Proteomics

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: Pap test, cervical swab, and tumor tissue LC-MS/MS proteomics from a case of high grade serous ovarian cancer.

ABSTRACT: The aim of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high grade serous ovarian cancer. A total of 4,934 proteins were identified and analyzed. This study is the first step in determining the feasibility of using the liquid-based Pap test or a cervical swab for the detection of ovarian cancer biomarkers

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Ovarian Cancer Cell, Uterine Cervix

SUBMITTER: Kristin Boylan  

LAB HEAD: Amy P.N. Skubitz

PROVIDER: PXD023272 | Pride | 2021-01-12

REPOSITORIES: Pride

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skubi002_boyla002_TumorTissue_T122591.msf Msf
skubi002_boyla002_TumorTissue_T122591_10_26.raw Raw
skubi002_boyla002_TumorTissue_T122591_11_27.raw Raw
skubi002_boyla002_TumorTissue_T122591_12_28.raw Raw
skubi002_boyla002_TumorTissue_T122591_13_29.raw Raw
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Publications

Evaluation of the potential of Pap test fluid and cervical swabs to serve as clinical diagnostic biospecimens for the detection of ovarian cancer by mass spectrometry-based proteomics.

Boylan Kristin L M KLM   Afiuni-Zadeh Somaieh S   Geller Melissa A MA   Argenta Peter A PA   Griffin Timothy J TJ   Skubitz Amy P N APN  

Clinical proteomics 20210107 1

<h4>Background</h4>The purpose of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high grade serous ovarian cancer. This study is the first step in determining the feasibility of using the liquid-based Pap test or a cervical swab for the detection of ovarian cancer protein biomarkers.<h4>Methods</h4>Proteins were concentrated by acetone precipitation from th  ...[more]

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