Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Jurkat Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Timothy Shaw
LAB HEAD: Jinghui Zhang
PROVIDER: PXD023377 | Pride | 2021-03-16
REPOSITORIES: Pride
Action | DRS | |||
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Eastogrp_082818_ip_b1.mzXML | Mzxml | |||
Eastogrp_082818_ip_b1.raw | Raw | |||
Eastogrp_082818_ip_b2.mzXML | Mzxml | |||
Eastogrp_082818_ip_b2.raw | Raw | |||
Eastogrp_082818_ip_b3.mzXML | Mzxml |
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Scientific reports 20210304 1
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of > 200 T-ALL transcriptomes linked USP7 haploinsufficiency with decreased activities of E-proteins. E-proteins are also negatively regulated by TAL1, leading to concerted down-regulation of E-protein target genes inv ...[more]