Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Bos Taurus (bovine)
SUBMITTER: Sandeep Misra
LAB HEAD: Joshua S. Sharp
PROVIDER: PXD023402 | Pride | 2022-02-16
REPOSITORIES: pride
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Tadi Surendar S Misra Sandeep K SK Sharp Joshua S JS
Analytical chemistry 20210209 7
Structural analysis of proteins in a conformationally heterogeneous mixture has long been a difficult problem in structural biology. In structural analysis by covalent labeling mass spectrometry, conformational heterogeneity results in data reflecting a weighted average of all conformers, complicating data analysis and potentially causing misinterpretation of results. Here, we describe a method coupling size-exclusion chromatography (SEC) with hydroxyl radical protein footprinting using inline f ...[more]