Proteomics

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Mining gastric cancer cellular quantitative proteomics data to analyse the proteome change upon CAMKK2 inhibition

ABSTRACT: Gastric cancer is a global health concern. Molecular alterations in various signaling pathways have been implicated in the development and late-stage progression/metastasis of gastric cancer. Reports have suggested that Wnt signaling pathway might contribute to gastric carcinogenesis by stimulating migration and invasion of gastric cancer cells. This study aimed at analysing the proteome change upon CAMKK2 inhibition in gastric cancer cells using LC-MS/MS based quantitative proteomic approach. A TMT based quantitative approach was used to identify the significantly altered proteins upon CAMKK2 inhibition. Gene Ontology (GO) analysis and pathway analysis was done for the significantly altered proteins and was later validated by immunoblotting.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Wall Of Stomach

DISEASE(S): Gastric Adenocarcinoma

SUBMITTER: Aditi Chatterjee  

LAB HEAD: Aditi Chatterjee

PROVIDER: PXD023423 | Pride | 2021-04-13

REPOSITORIES: Pride

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Dataset's files

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CAMKK2_TP_bRPLC10_R1.raw Raw
CAMKK2_TP_bRPLC10_R2.raw Raw
CAMKK2_TP_bRPLC10_R3.raw Raw
CAMKK2_TP_bRPLC11_R1.raw Raw
CAMKK2_TP_bRPLC11_R2.raw Raw
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Publications

Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.

Najar Mohd Altaf MA   Modi Prashant Kumar PK   Ramesh Poornima P   Sidransky David D   Gowda Harsha H   Prasad T S Keshava TSK   Chatterjee Aditi A  

Journal of proteome research 20210412 5

Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. We showed previously that calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), a serine-threonine kinase, is highly expressed in gastric cancer and leads to progression. In the present study, we identified the molecular networks involved in CAMKK2-mediated progression of gastric adenocarcinoma. Treatment of gastric cancer cell lines with a CAMKK2 inhibitor, STO-609, resulted in  ...[more]

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