Dataset Information
Prevention of high fat diet induced obesity and associated disease by the major cap-binding protein
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Juan Oses-Prieto
LAB HEAD: Davide Ruggero
PROVIDER: PXD023440 | Pride | 2023-10-05
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Set-B-proteins-FDR1percent.xlsx | Xlsx | |||
| Set_A-proteins-FDR1percent.xlsx | Xlsx | |||
| Z20191021-06_FTMSms2hcd.RAW | Raw | |||
| Z20191021-07_FTMSms2hcd.RAW | Raw | |||
| Z20191021-08_FTMSms2hcd.RAW | Raw |
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Publications
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Nature metabolism 20210218 2
Obesity is a global epidemic leading to increased mortality and susceptibility to comorbidities, with few viable therapeutic interventions. A hallmark of disease progression is the ectopic deposition of lipids in the form of lipid droplets in vital organs such as the liver. However, the mechanisms underlying the dynamic storage and processing of lipids in peripheral organs remain an outstanding question. Here, we show an unexpected function for the major cap-binding protein, eIF4E, in high-fat-d ...[more]
