Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Ribosome
DISEASE(S): Trichothiodystrophy
SUBMITTER: Christina Ludwig
LAB HEAD: Christina Ludwig
PROVIDER: PXD023451 | Pride | 2021-11-16
REPOSITORIES: Pride
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BBM_270_P153_01_HEK_001.raw | Raw | |||
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Nucleic acids research 20211101 19
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations in TFIIH and TFIIE give rise to the degenerative disorder trichothiodystrophy (TTD). Here, we uncovered an unexpected role of TFIIE in ribosomal RNA synthesis by RNA polymerase I. With high resolutio ...[more]